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Catheter Cardiovasc Interv

Fully automatic three-dimensional quantitative analysis of intracoronary optical coherence tomography: method and Validation

K. Sihan, Charl P. Botha, Frits H. Post, Sebastiaan de Winter, Gonzalo Nieves, E Regar, Patrick J W C Serruys, R Hamers, and N Bruining

To close the remaining gaps, the straight line at the right-hand side (A), a circular arc interpolation is performed automatically using the center of gravity of the contour as the center of the circle (B). For the radius, linear interpolation is used from r1 to r2. The repaired contour is presented in (C)

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Quantitative analysis of intracoronary optical coherence tomography (OCT) image data (QOCT) is currently performed by a time-consuming manual contour tracing process in individual OCT images acquired during a pullback procedure (frame-based method). To get an efficient quantitative analysis process, we developed a fully automatic three-dimensional (3D) lumen contour detection method and evaluated the results against those derived by expert human observers. Methods: The method was developed using Matlab (The Mathworks, Natick, MA). It incorporates a graphical user interface for contour display and, in the selected cases where this might be necessary, editing. OCT image data of 20 randomly selected patients, acquired with a commercially available system (Lightlab imaging, Westford, MA), were pulled from our OCT database for validation. Results: A total of 4,137 OCT images were analyzed. There was no statistically significant difference in mean lumen areas between the two methods (5.03 +- 2.16 vs. 5.02 +- 2.21 mm power 2; P = 0.6, human vs. automated). Regression analysis showed a good correlation with an r value of 0.99. The method requires an average 2–5 sec calculation time per OCT image. In 3% of the detected contours an observer correction was necessary. Conclusion: Fully automatic lumen contour detection in OCT images is feasible with only a select few contours showing an artifact (3%) that can be easily corrected. This QOCT method may be a valuable tool for future coronary imaging studies incorporating OCT.

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Citation

K. Sihan, Charl P. Botha, Frits H. Post, Sebastiaan de Winter, Gonzalo Nieves, E Regar, Patrick J W C Serruys, et al., Fully automatic three-dimensional quantitative analysis of intracoronary optical coherence tomography: method and Validation, Catheter Cardiovasc Interv, 74, pp. 1058–65, 2009.

BibTex 

@article{bib:sihan:2009,
    author       = { Sihan, K. and Botha, Charl P. and Post, Frits H. and de Winter, Sebastiaan and Nieves, Gonzalo and Regar, E and Serruys, Patrick J W C and Hamers, R and Bruining, N },    
    title        = { Fully automatic three-dimensional quantitative analysis of intracoronary optical coherence tomography: method and Validation },
    journal      = { Catheter Cardiovasc Interv },
    volume       = { 74 },
    year         = { 2009 },
    pages        = { 1058--65 },
    doi          = { 10.1002/ccd.22125 },
    pubmedid     = { 19521990 },
    url          = { https://publications.graphics.tudelft.nl/papers/421 },
}