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In Proceedings of ICIAR (2)

Digitisation and 3D Reconstruction of 30 Year Old Microscopic Sections of Human Embryo, Foetus and Orbit

Joris van Zwieten, Charl P. Botha, Ben Willekens, Sander Schutte, Frits H. Post, and Huib Simonsz

From left to right, the five steps of the segmentation procedure: input section, thresholding on hue, binary dilation to close contour, background artifact removal, filling the remaining holes in the mask

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A collection of 2200 microscopic sections was recently recovered at the Netherlands Ophthalmic Research Institute and the Department of Anatomy and Embryology of the Academic Medical Centre in Amsterdam. The sections were created thirty years ago and constitute the largest and most detailed study of human orbital anatomy to date. In order to preserve the collection, it was digitised. This paper documents a practical approach to the automatic reconstruction of a 3-D representation of the original objects from the digitised sections. To illustrate the results of our approach, we show a multi-planar reconstruction and a 3-D direct volume rendering of a reconstructed foetal head.

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Joris van Zwieten, Charl P. Botha, Ben Willekens, Sander Schutte, Frits H. Post, and Huib Simonsz, Digitisation and 3D Reconstruction of 30 Year Old Microscopic Sections of Human Embryo, Foetus and Orbit, In Proceedings of ICIAR (2), pp. 636–647, 2006.

BibTex 

@inproceedings{bib:van zwieten:2006,
    author       = { van Zwieten, Joris and Botha, Charl P. and Willekens, Ben and Schutte, Sander and Post, Frits H. and Simonsz, Huib },    
    title        = { Digitisation and 3D Reconstruction of 30 Year Old Microscopic Sections of Human Embryo, Foetus and Orbit },
    booktitle    = { In Proceedings of ICIAR (2) },
    year         = { 2006 },
    pages        = { 636--647 },
    doi          = { 10.1007/11867661_57 },
    dblp         = { conf/iciar/ZwietenBWSPS06 },
    url          = { https://publications.graphics.tudelft.nl/papers/466 },
}