NMR Biomed

Diffusion tensor imaging of left ventricular remodeling in response to myocardial infarction in the mouse

G.J. Strijkers, A. Bouts, W. Matthijs Blankesteijn, T.H.J.M. Peeters, Anna Vilanova, M.C. van Prooijen, H.M.H.F. Sanders, E. Heijman, and K. Nicolay

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The mouse offers a unique platform to study the functional development of the healthy and diseased heart. The cardiac muscle architecture lies at the basis of the mechanical and electrical properties of the heart and dynamic alterations in fiber structure are known to be of prime importance in the healing and remodeling following myocardial infarction. Diffusion tensor imaging (DTI) offers a non-destructive tool to study both myocardial fiber orientations [1-3] as well as to evaluate structural changes of the muscle tissue caused by ischemia [4]. In this study left ventricular remodeling was studied using diffusion tensor imaging (DTI) in a permanent ligation mouse model of ischemic infarction up to 28 days post infarction.

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@article{bib:strijkers:2009,
    author       = { Strijkers, G.J. and Bouts, A. and Blankesteijn, W. Matthijs and Peeters, T.H.J.M. and Vilanova, Anna and van Prooijen, M.C. and Sanders, H.M.H.F. and Heijman, E. and Nicolay, K. },    
    title        = { Diffusion tensor imaging of left ventricular remodeling in response to myocardial infarction in the mouse },
    journal      = { NMR Biomed },
    volume       = { 22 },
    year         = { 2009 },
    pages        = { 182--90 },
    doi          = { 10.1002/nbm.1299 },
    pubmedid     = { 18780284 },
    url          = { https://publications.graphics.tudelft.nl/papers/602 },
}