In Proceedings of Medical Imaging: Image-Guided Procedures

Integrated visualization of multi-angle bioluminescence imaging and micro CT

Peter Kok, Jouke Dijkstra, Charl P. Botha, Frits H. Post, E.L. Kaijzel, I. Que, C.W.G.M. Lowik, J.H.C. Reiber, and Boudewijn P. F. Lelieveldt

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This paper explores new methods to visualize and fuse multi-2D bioluminescence imaging (BLI) data with structural imaging modalities such as micro CT and MR. A geometric, back-projection-based 3D reconstruction for superficial lesions from multi-2D BLI data is presented, enabling a coarse estimate of the 3D source envelopes from the multi-2D BLI data. Also, an intuitive 3D landmark selection is developed to enable fast BLI / CT registration. Three modes of fused BLI / CT visualization were developed: slice visualization, carousel visualization and 3D surface visualization. The added value of the fused visualization is demonstrated in three small-animal experiments, where the sensitivity of BLI to detect cell clusters is combined with anatomical detail from micro-CT imaging.

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@inproceedings{bib:kok:2007,
    author       = { Kok, Peter and Dijkstra, Jouke and Botha, Charl P. and Post, Frits H. and Kaijzel, E.L. and Que, I. and Lowik, C.W.G.M. and Reiber, J.H.C. and Lelieveldt, Boudewijn P. F. },    
    title        = { Integrated visualization of multi-angle bioluminescence imaging and micro CT },
    booktitle    = { In Proceedings of Medical Imaging: Image-Guided Procedures },
    year         = { 2007 },
    pages        = { 65091U },
    doi          = { 10.1117/12.711117 },
    dblp         = { conf/miigp/KokDBPKQLRL07 },
    url          = { https://publications.graphics.tudelft.nl/papers/717 },
}