In Proceedings of Dutch Conference on Bio-Medical Engineering

Pharmacokinetic analysis of dynamic contrast-enhanced (DCE) MR breast images

M. Heisen, J. Buurman, T. Twellmann, Anna Vilanova, F.A. Gerritsen, and B.M. ter Haar Romeny

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DCE-MR breast imaging is becoming an important modality as a problem-solving tool and in screening of high-risk patients. In DCE-MR a T1-weighted time series is recorded during the uptake of a contrast agent (CA: Gd-DTPA) that enables the assessment of voxel-specific dynamic tissue properties. Tumor malignancy often goes hand in hand with high vascularity and high vessel wall permeability because of angiogenesis; i.e. a large number of new vessels is formed at such a rate that their walls are not properly constructed and therefore highly permeable. These ‘malignant’ tissue characteristics affect the shape of the CA-uptake curve. The goal is to investigate the use of a pharmacokinetic two-compartment model (extended Kety [1]) in the context of dynamic analysis of CA-uptake curves as a contribution to automatic detection and characterization of breast cancer.

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@inproceedings{bib:heisen:2007,
    author       = { Heisen, M. and Buurman, J. and Twellmann, T. and Vilanova, Anna and Gerritsen, F.A. and ter Haar Romeny, B.M. },    
    title        = { Pharmacokinetic analysis of dynamic contrast-enhanced (DCE) MR breast images },
    booktitle    = { In Proceedings of Dutch Conference on Bio-Medical Engineering },
    year         = { 2007 },
    pages        = { 8282 },
    note         = { BME 2007, Egmond aan zee, The Netherlands },
    url          = { https://publications.graphics.tudelft.nl/papers/726 },
}